\(\displaystyle 4= 2^2\) so \(\displaystyle 4^x= (2^2)^x= 2^{2x}= (2^x)^2\).
\(\displaystyle 2^{x+ 2}= (2^x)(2^2)= 4(2^x)\)
So your equation is the same as \(\displaystyle (2^x)^2+ 4(2^x)= 8\). If you let \(\displaystyle y= 2^x\), that is \(\displaystyle y^2+ 4y= 8\).
Solve that quadratic equation for y, perhaps by "completing the square", then solve for x. The answers are NOT simple integer numbers!