Here is the most intuitive description as far as I am concerned.
Imagine a very small number, so small it is no longer finite and is indistinguishable from zero but is not equal to zero. The difference is too small to measure.
Differential calculus is about dividing two such infinitessimals. We are dividing what is indistinguishable from zero by something that is also indistinguishable from zero.
Integral calculus is about multiplying an infinitessimal by infinity.
Multiplication and division are inverse operations.
That seems to have been how the inventors of calculus actually thought about what they were doing. It has been formalized in non-standard analysis, which defines infinitessimals and provides an arithmetic for them. A much more common formalization deals with limits. It says if you divide a very small but finite number by another very small but finite number and the quotient stabilizes as the numbers get smaller and smaller in a systematic way, the division has a limiting value. Similarly, if you multiply a number of very small magnitude by a number of very great magnitude and the product stabilizes as the one number gets smaller and the other number gets bigger ina systematic way, the product has a limit. The deriviative and the integral are simply formulas for these limits with respect to certain functions.
That is super-informal. Mathematicians have, however, developed these ideas rigorously. I am just giving my personal intuition.
Geometrically, the definite integral is the area between a curve, the x-axis, and a starting and ending point. The derivative is the slope of the tangent to the curve at a point.
Rate of change comes in when the x-axis represents time and the y-axis represents something dependent on time. The slope of the tangent is defined to be the instantaneous rate of change. It is not an intuition but rather a definition that gives useful empirical results.
Now the other helpers will explain why I am totally wrong.