when doing partial derivatives, you just derive according to the selected variable while holding all other(s) constant.
in your equation:
f(x,y)= x[sup:1o31cau9]2[/sup:1o31cau9] + (5x[sup:1o31cau9]4[/sup:1o31cau9])y (i'm assuming it's times y)
fx = 2x + (20x[sup:1o31cau9]3[/sup:1o31cau9])y
fx evaluated at (x,y) = (3,4) is
2(3) + 20(27)(4) = 2166