You need to do this by whatever method you have been taught. We don't know what that is.
You may have been given a set of formulas. Or, you may have been shown how to use some particular statistics software, or even spreadsheet software, or a graphing calculator, to do it.
Can you tell us something about what you have been taught, or what you were told to use in this course?
You say this is for calculus, rather than for statistics as I would expect. The same questions still apply.
This page explains Least-Squares Regression, shows a worked example and organizes the steps for paper-and-pencil work. There's also a regression calculator, for checking your answer.
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