You could start by finding the equation in slope intercept form.
y = mx + c
Use the two points to find the slope, (y/x)
(-2-4)/(5-1) = -(6/4) = -(3/2)
y = -(3/2)x + c
Substitute one of the points, (1, 4) and solve for, c, the y intercept.
4 = -(3/2) + c
c = (11/2)
Equation is
y = -(3/2)x + (11/2)
Rearrange to Ax + By = C
Multiply through by 2
2y = -3x + 11
Add 3x to both sides.
3x + 2y = 11