This is a linear equation. It can be solved be separating into "homogeneous" and "non-homogeneous" parts as Rumsek suggests.
You can also find an "integrating factor, a function, h(x), such that multiplying by it, to get
\(\displaystyle h(x)y'+ 5h(x)y= 4h(x)e^{.8x}\) has an "exact derivative", so that d(hy)/dx= h dy/dx+ 5hy, on the left.
From the product rule, d(hy)/dx= h dy/dx+ (dh/dx)y= h dy/dx+ 5h y so we must have dh/dx= 5x.