[I always use the "prime" notation to indicate the derivative with respect to the independent variable of the function .. that is, y' indicates dy/du, and u'=du/dx. To avoid confusion, lets bypass the primes.]
The error I see is that the "3" from dy/du must also be multiplied by du/dx:
\(\displaystyle \displaystyle \dfrac{dy}{dx} = \dfrac{dy}{du}\times \dfrac{du}{dx} = (10u + 3)\times \dfrac{du}{dx}\)
.....\(\displaystyle \displaystyle = \left(10\dfrac{18}{x^2 + 5} + 3\right)\times \left(\dfrac{-36x}{(x^2 + 5)^2} \right) \)
When you evaluate at x=2, will that give you the right answer?